Monday, 1 September 2008

Prom 53: RPO/Gatti, Royal Albert Hall, London

Daniele Gatti took over the Royal Philharmonic Orchestra in 1996, inheriting an orchestra stuck in the artistic doldrums, living off soupy performances of exactly the kind of workings presented on Monday night's concert. Choosing both the Tchaikovsky and Prokofiev's Romeo and Juliet for his final Prom as the RPO's principal - he takes over from Kurt Masur next month at the Orchestre National de France - Gatti was well able to show just how far his orchestra has come these past 12 years.

Not a trace of soup was to be found in either process. The Prokofiev was crisp, rhythmically elating and, despite the periodic unevenness, delicately balanced, the orchestra riding confidently over the unceasing alterations of texture, alive to the often unmarked contrapuntal complexity of the score. While there were no dancers in this arrangement of excerpts from the concert dance, Gatti's light of come to allowed the melodies allow for to spin off round the hallway, waltzing gaily but ne'er losing liaison with their well-drilled accompaniment.

The Tchaikovsky was taken, particularly in the outer movements, at a blistering stride. Stripped of sentimentality, the complex chain of flimsy, difficult sentiment that makes up the work was presented with the raw-edged candour it merits. The orchestra was electric, the strings - Gatti among them with the occasional air-violin contribution - on masterful bod whether sweeping, soaring or plucking through and through some of the trickiest pizzicato passages in the repertoire. The brass gently warmed the texture or smashed clean through it with convinced blasts, and the woodwind instrument, too, were very much alive to the demands of Tchaikovsky's generously orchestrated score. Gatti, conducting from memory, was on flame.







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Friday, 22 August 2008

Download 4 Non Blondes mp3






4 Non Blondes
   

Artist: 4 Non Blondes: mp3 download


   Genre(s): 

ROck: Alternative

   







Discography:


Bigger, Better, Faster, More!
   

 Bigger, Better, Faster, More!

   Year: 1992   

Tracks: 11






4 Non Blondes howled their way onto the charts in 1993 with "What's Up?" and then vanished without a rustle. Formed in 1989 with Linda Perry (vocals), Shaunna Hall (guitar), Christa Hillhouse (bass), and Wanda Day (drums), 4 Non Blondes had no problems attracting major labels based on live shows and local radio supporting from KUSF, merely the labels didn't know how to food market them. After Day was replaced by Dawn Richardson, the group was eventually sign-language to Interscope Records and released Larger, Better, Faster, More? in 1992. Although Hall contributed guitar tracks and some songs, she left ahead the album was released (replaced by Roger Rocha for the lap). Dominated by Perry's high-pitched telling, "What's Up?" was slow added to mod tilt stations of the Cross and then crossed over into the mainstream, peaking at recognition number 11 on the Billboard Top cc. The video for "What's Up?" became a demolish on MTV, propellant sales of the record album to over sextet million copies world. "What's Up?" was selected as Best Song by the Bay Area Music Awards; what is more, Perry was chosen as Best Female Vocalist and Larger, Better, Faster, More? north Korean won for Best Album. The grouping toured with Neil Young, Pearl Jam, and Bob Dylan. The band recorded tunes for the soundtracks to Wayne's World 2 and Airheads. However, Perry felt that the chemical group had get also bulge; consequently, she left 4 Non Blondes. She released her solo debut, In Flight, in 1995. Perry kaput from Interscope Records in 1998 and recorded her mo uncut, After Hours, for her possess






Tuesday, 12 August 2008

Posh, Parker starting a club business

Washington (ANI): Former Spice Girl Victoria Beckham is starting a club business in coaction with Desperate Housewives ace Eva Longoria Parker. The pair, world Health Organization are close friends, are said to be planning a fondness new nightspot in Las Vegas.

According to Contactmusic, the club will contain Longoria Parker's restaurant Beso, and a high-rollers casino. Meanwhile, Posh's representatives have denied that she is set to star in 'High School Musical 3: Senior Year'.

Her interpreter insists that she has not been offered a role in the film. "She has not been approached, merely the Beckham boys ar big fans of High School Musical," Contactmusic quoted the illustration, as saying.



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Wednesday, 6 August 2008

DISRUPT

DISRUPT   
Artist: DISRUPT

   Genre(s): 
Metal
   



Discography:


Unrest   
 Unrest

   Year: 1994   
Tracks: 30




 





Lorena

The Wallflowers

The Wallflowers   
Artist: The Wallflowers

   Genre(s): 
Rock: Pop-Rock
   



Discography:


Rebel, Sweetheart   
 Rebel, Sweetheart

   Year: 2005   
Tracks: 12


Bringing Down The Horse   
 Bringing Down The Horse

   Year:    
Tracks: 11




 






Parkinson's Disease: Blood-Related Genetic Mechanisms Important

�What does the genetics of blood cells receive to do with brain cells related to Parkinson's disease? From an unusual collaboration of neurologists and a pharmacologist comes the surprising serve: Genetic mechanisms at run in blood cells also control a gene and protein that cause Parkinson's disease.





The determination, by scientists from the University of Wisconsin School of Medicine and Public Health (SMPH), Harvard University-affiliated Brigham and Women's Hospital and the University of Ottawa, may lead to new treatments for the neurological disorder that affects as many as 1.5 jillion Americans.





The study is published in the Proceedings of the National Academy of Sciences Online Early Edition the week of July 21-25, 2008.





Patients with Parkinson's disease (PD) have elevated levels of the protein called alpha-synuclein in their brains. As the protein clumps, or aggregates, the resulting toxicity causes the death of neurons that produce the brain chemic dopamine. Consequently, nerves and muscles that control movement and coordination are destroyed.





The researchers observed that the activity of three genes that control the synthetic thinking of haemitin, the major component of hemoglobin that allows red River blood cells to convey oxygen, exactly matched the activity of the alpha-synuclein gene, suggesting a common switch controlling both.





The scientists then establish that a protein called GATA-1, which turns on the cognate genes, was also a major switch for alpha-synuclein expression, and that it induced a significant growth in alpha-synuclein protein. Finally, they demonstrated that a related protein - GATA-2 - was expressed in PD-vulnerable encephalon cells and directly controlled alpha-synuclein production.





"Very little was known previously about what turns on alpha-synuclein in brain cells and causes variations in its expression," says Emery Bresnick, a UW-Madison professor of pharmacology who is an technical on GATA factors and their functions in blood. "Understanding how GATA factors work in the brain may bring home the bacon fundamental insights into the biology of Parkinson's disease."





The new cognition also crataegus laevigata allow scientists to plan therapies that keep alpha-synuclein levels within the normal range.





"Simply lowering alpha-synuclein levels by 40 percent whitethorn be enough to regale some forms of Parkinson's disease," says Dr. Clemens Scherzer of Harvard. "So far, researchers have focussed on shipway to get rid of too much 'bad' alpha-synuclein in Parkinson patients' brains. Now we will be able to tackle the problem from the production site, and search for new therapies that lour alpha-synuclein production up front."





Scherzer and Dr. Michael Schlossmacher, now at Ottawa, had independently analyzed the blood of PD patients and controls in a search for genes that were active in the disease. They both were surprised to notice large amounts of alpha-synuclein in the blood. To understand what it was doing there, Scherzer's group used factor chip information to learn whether whatever of the thousands of genes alive in blood were linked to alpha-synuclein. They establish a factor expression rule composed of alpha-synuclein and the heme genes, ane of which Bresnick had previously shown to be a train GATA-1 quarry gene.





The neurologists contacted Bresnick. The UW group quickly determined that GATA-1 at once activated the alpha-synuclein factor, and that finding lED the collaborators to discover that GATA-2 is expressed in regions of the brain that are relevant to PD.





"We all were excited because we completed that GATA-2 was active in the relevant mastermind regions, and so on that point could be a connection," says Bresnick. Together the researchers set out to examine whether common mechanisms activated alpha-synuclein transcription in both the blood and nerve cells.





The studies showed that GATA-1 and GATA-2 proteins find the alpha-synuclein gene, sting to it and then directly control it.





"This is not an indirect pathway; it is direct regulation of the gene," says Bresnick. "This directness provides the simplest scenario for creating a therapeutic strategy."





Bresnick, Schlossmacher and Scherzer are working with geneticists to see if possible abnormalities in the GATA-2 cistron may exist in PD patients, stimulating more production of alpha-syinuclein.





"The discovery of the connectedness between GATA proteins and the alpha-synuclein gene is like finding a long-sought-after molecular switch," says Schlossmacher. "We were very rosy to line up in Emery Bresnick's team the ideal partner in this endeavor."





The family of GATA factors consists of six members, and some of them, beyond GATA-2, may likewise be influencing alpha-synuclein construction in the brain, adds Schlossmacher.





"Identifying these would further add to the complexness of regulating the production of the 'bad player' in Parkinson's disease," he says.





Says Bresnick, "The $10 million query will be: Does deregulation of the GATA mechanics in man lead to alpha-synuclein overrun and Parkinson's disease?"









Source: Dian Land



University of Wisconsin-Madison





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Thursday, 3 July 2008

Jackass - Steve-o Hit With Assault Lawsuit


JACKASS star STEVE-O is facing more legal troubles - a security guard is suing him over an alleged assault at the launch of PARIS HILTON's clothing line.

Doorman Roland Cano was hired to work at the Kitson store in Los Angeles in August 2007 to provide extra security while Hilton unveiled her fashion range.

Cano has accused Steve-O - real name Stephen Glover - of attacking him when he was denied access to the event.

Glover was reportedly filming reality show Dr. Steve-O at the time and Cano has also named TV network NBC and the star's bodyguard in the suit, which was filed at L.A. County Superior Court on Tuesday (01Jul08).

Cano alleges in the papers that Glover "without provocation, violently punched (his) head repeatedly" and is suing the stuntman for unspecified damages, according to TMZ.com.

Glover will soon be forced to enter rehab after entering a guilty plea to felony drug charges relating to an incident in March (08) in which he allegedly vandalised a neighbour's property.





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Wednesday, 2 July 2008

Philharmonia/Maazel, Royal Festival Hall, London

Lorin Maazel's three Philharmonia Brahms concerts, the four symphonies followed by the Haydn Variations and the German Requiem, were billed as "Brahms: the Romantic", but in the hall they came across more as Brahms the classicist. Three back-to-back Brahms concerts makes one realise yet again that no composer is as self-disciplined. None makes more out of such small motifs - the opening movement of the fourth symphony is the greatest triumph of this approach - and none is as unsparingly attentive to the forward-looking use of older musical forms, as the fourth's closing movement (expertly navigated by Maazel) proves.












On the basis of his showman reputation, Maazel might not seem an obvious choice in this repertoire. But his controlled and controlling way of making music actually suits Brahms well. As Maazel wrote in the programme essay, Brahms works best when conductors avoid rhetorical flourishes and decline to pump up the phrases or dawdle sentimentally. Disciplined drive is the key to Brahms, and that is what Maazel and the Philharmonia delivered.

That approach worked most successfully in the first and fourth symphonies, less happily in the more expansive second. Yet the performances were never less than interesting. The Philharmonia players responded to Maazel's concentrated approach with some superbly disciplined playing, particularly in the lower strings and the woodwind.

Maazel's strict direction was a virtue in the requiem, too, preventing this great work from billowing aimlessly, as it sometimes can. Both the outstanding Simon Keenlyside and, after a faltering start, Heidi Grant Murphy sang their difficult solos with the combination of seriousness and eloquence that is the hallmark of Brahms.


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Fresh and Baron

Fresh and Baron   
Artist: Fresh and Baron

   Genre(s): 
Drum & Bass
   



Discography:


Fresh and Baron-BBK006P   
 Fresh and Baron-BBK006P

   Year: 2005   
Tracks: 2




 






Chat To Infadels At 4pm Today (July 2nd) On Gigwise

We're excited to announce that this week's Tuborg Webchat Wednesday will star Gigwise favourites Infadels.



The band, who recently released their second album 'Universe In Reverse', will be online with us from 4pm today (July 2nd).



To take part in the webchat just go to http://chat.gigwise.com with all your pressing questions and log in.



See you in there!




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AnneEx Card -- Don't Go to the Drugstore With It

The charity of Anne Hathaway's ex -- and current subject of a federal indictment -- Raffaello Follieri is making bogus claims -- shocker, we know.

The Follieri Foundation's website claims that it hands out discount drug cards for free to whomever needs them. We asked a bunch of Manhattan drugstores if they knew about the Follieri cards -- total silence. And get this -- the company that partners with Follieri in the card project doesn't exist anymore.

Calls to the Follieri Group yielded a busy signal despite repeated attempts. The New York Attorney General's office wouldn't comment on its ongoing investigation of the Zach Braff-alike, who's waiting to make his $21 mil bail.





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Simpson�s shirt upsets Anderson









Pamela Anderson has branded Jessica Simpson a �b---h and w---e,� femalefirst.co.uk reports. The former Baywatch babe is furious the With You singer wore a T-shirt emblazoned with the slogan, Real Girls Eat Meat.

Anderson � an active campaigner for animal rights group PETA � said: �I think she is a b---h and a w---e. Actually, I don�t know if she was talking about food or men.�

The 40-year-old actress says she is proud to be a vegetarian, insisting it is a good lifestyle choice for everybody.

She told an Australian radio show: �I think it�s healthy, good for your body and good for the environment.�

Simpson was recently blasted by PETA for wearing the T-shirt.

The blond beauty � who famously questioned why tuna was nicknamed �chicken of the sea� on her reality TV show Newlyweds � came under fire from the animal rights group, which urged her to ditch meat to increase her brain power.










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Slut

Slut   
Artist: Slut

   Genre(s): 
Other
   



Discography:


Nothing Will Go Wrong   
 Nothing Will Go Wrong

   Year: 2002   
Tracks: 10


Lookbook   
 Lookbook

   Year: 2001   
Tracks: 15


All We Need Is Silence   
 All We Need Is Silence

   Year:    
Tracks: 10




 





Boyz II Men

Dirty Pretty Things, Romance At Short Notice

The good news first: the second offering from this band since Messrs Barat and Doherty parted company and began their quest to find the worst band names in the world is a crisp, polished collection of tuneful japery and pithy urban commentary. So what makes this vaguely disappointing overall?

The album is brim with dazzling time signature jiggery pokery, like the fairground whooze of opener, Buzzards And Crows as well as the semi-literary allusions to old Albion on Tired Of England; though Barat's vision has on very London-centric goggles, borrowing from Samuel Johnson's old adage. His wordiness is witty and spry, but sometimes one can't help feeling that he's overcompensating for a certain missing lyricist. Not only that, but the spray of words on tracks like Truth begins smacks too much of Alex Turner's more verbose moments. You can't help but be disappointed by a band who seem to be eclipsed by their peers. Best Face tries to weld a Battles/Vampire Weekend post/math rock to Barat's Clash-like punk rush, but while it's impressively played it falls short of a seamless whole.



On this note it's interesting to note how this album exhibits a studied competence that betrays how far they've come as a unit. Far from shambolic (or stymied by alcohol-fuelled bone breakages), at the heart of Romance At Short Notice is a cheerily efficient pop heart. Like their debut, every track sports ragged, squally tops and tails, but when things get going the chaos is revealed as being actually very together. Only on Chinese Dogs and the stubbornly dissonant Faultlines does it seem that the music matches the usual tales of dissolution and disillusion. Carl's ragged roar on Hippy's Son is also suitably bile-spewing.

Yet, a little too often the jauntiness puts you in mind of those jolly fillers that Oasis used to stick on their albums to make up the numbers. Plastic Hearts 'La-la-la's will sound great at that sweaty gig, but grate in studio-bound form. Maybe Carl and P***'s chapter in Britpop has truly passed. But it would be a shame to see a band as lithe and keen as DPT sound here wilt into obscurity. Romance At Short Notice shows them just beginning to really find a voice.


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